Mayim Bialik as Amy Farrah Fowler
As introduced in season three, Amy Farrah Fowler was discovered as a potential match for Sheldon by Raj and Howard on a dating site. Played by Mayim Bialik, Amy’s character holds a doctorate in neurobiology from Harvard – a nod to Bialik’s own educational background. Despite her frumpy fashion sense, Amy becomes a regular member of the group and Sheldon’s girlfriend while also being Penny’s self-proclaimed best friend. Her interactions with Penny and Bernadette lead her to embrace new experiences, and her subtle humor and endearing quirks make it impossible not to adore Amy. As the series progresses, she gradually breaks down many of Sheldon’s walls, culminating in their engagement during the show’s tenth season.